CIPF conferencia Profesor Claudio Stern (University College de Londres, Reino Unido)
Speaker: Profesor Claudio Stern Affiliation
Date: 17/02/2015 – 13h
Place: Salón de Actos CIPF
Amniote (higher vertebrate) embryos can give rise either to a single or to multiple individuals (twins) until the start of gastrulation (primitive streak formation). This reveals not only “pluripotency” of cell fates, but an even more striking potential of the embryo to self-organize into a complete organism. This can be viewed as an extreme case of regeneration: parts of the embryo can regenerate the entire body and form another individual. But then, what mechanisms prevent this during normal development? We will review some recent progress in understanding the molecular and cellular mechanisms that coordinate fate, polarity and pattern in the embryo and which also regulate twinning. Specifically, we will describe a novel molecular screening strategy used to identify upstream regulators of the earliest known gene that predicts embryonic polarity in the chick embryo, Vg1/GDF1. The results reveal unexpected parallels between the mechanisms that establish left-right asymmetry and those that position the embryonic axis, as well as crucial regulatory elements conserved in mammals including humans.
Más información: http://www.cipf.es/es/