Conferencia en CIPF- Human pluripotent stem cell based tools for retinal & corneal applications
The Future of Biomedical Research Lecture Series
Speaker: Dra. Heli Skottman
BioMediTech, University of Tampere, Finland
Date: Tuesday 05/04/16 – 12:30h
Place: Salón de Actos CIPF
Tissue engineering and stem cells are a potential approach for the replacement of degenerated cells of the eye and to study ophthalmic diseases. Tissue specific stem cells and human pluripotent stem cells (hPSC) both have their own benefits and drawbacks. For corneal defects, shortage of donated human corneas for transplantation has driven the search of novel cell sources including hPSC. In healthy cornea, epithelium is renewed by limbal stem cells (LSCs) and LSCs transplantation has been used to treat limbal stem cell deficiency (LSCD). However, this is only possible if enough healthy limbal tissue is available. Thus hPSC provide unique opportunities for differentiation of limbal and corneal epithelial cells. For retinal diseases such as age related macular degradation, the usability of hPSC are widely studied. In this area, the first clinical trials using hPSC derived retinal pigment epithelial cells (RPE) are ongoing and new trials are starting. The lecture will give an overview of current state of the stem cell research in ophthalmology and special demands regarding cells and biomaterials used in these applications highlighting experience gained from hPSC based RPE and LSC studies.