The multicellular complexity of peripheral nerve regeneration
Speaker: Prof. Alison Lloyd LMCB, University College London, London, UK
Date: 07/07/2015 – 13h
Place: Salón de Actos CIPF
Abstract: The regeneration of a tissue following an injury requires the repair or replacement of the damaged or lost cellular structures. Peripheral nerves, unlike those of the CNS, are one of the few tissues in mammals capable of extensive regeneration, in that even following an injury as severe as a complete transection, the damaged nerves are able to reconnect with their original targets. However, this does not involve regeneration of the entire nerve structure downstream of the cut, instead the distal stump remains intact, reconnects with the proximal stump via a “bridge” of new tissue, and is remodelled to provide a suitable environment to guide and support regrowing axons back to their targets. A major hurdle in this process is the guidance and support of the axons across the “bridge” prior to entering into the distal stump of the nerve and it has been unclear how this is achieved. I will talk about our work on the complex multicellular interactions required for regeneration of peripheral nerves, how Schwann cells are key central regulators and how tumourigenesis in this tissue mimics activation of various aspects of this remarkable regenerative process.