Neuroprosthetic technologies to improve locomotion after spinal cord injury
Swiss Federal Institute of Technology, Lausanne, Switzerland
Date: Monday 14/09/15 – 13h
Place: Salón de Actos CIPF
Over the past decade, we have designed a range of robot-assisted rehabilitation procedures and neuromodulation therapies of the brainstem and spinal cord. We showed that the combination of these neuroprosthetic technologies restored supraspinal control of locomotion in rats with a spinal cord injury leading to permanent paralysis. This recovery relied on the extensive remodeling of spared neuronal pathways in the brain and spinal cord. The successful implementation of these interventions required the development of myriad tools, including neural interfaces, computational models, real-time control platforms, robotic systems, and advanced anatomical analyses. Here, I will describe the mechanistic framework through which we designed these technologies. I also will reveal some of the mechanisms underlying the immediate and long-term effects of neuroprosthetic rehabilitation on motor control capacities. Finally, I will highlight our current efforts to translate our findings in rodent models into a viable therapy to improve the recovery of locomotion in human patients with spinal cord injury.
Our mailing address is:
Calle de Eduardo Primo Yúfera, 3 (junto Oceanográfico)
Valencia, Valencia 46012